Magainin 2 (Xenopus laevis)
Magainin II
CAS: 108433-95-0
Molecular Formula: C114H180N30O29S
Magainin 2 (Xenopus laevis) - Names and Identifiers
Magainin 2 (Xenopus laevis) - Physico-chemical Properties
| Molecular Formula | C114H180N30O29S |
| Molar Mass | 2466.9 |
| Density | 1.275±0.06 g/cm3(Predicted) |
| Boling Point | 2444.0±65.0 °C(Predicted) |
| Storage Condition | -20°C |
| MDL | MFCD00133522 |
| Physical and Chemical Properties | Bioactive Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from Xenopus laevis skin. Magainin 2 showed antibiotic activity against many Gram-negative and Gram-positive bacteria. Magainin 2 is also active against protozoa. Magainin 2 exerts a cytotoxic effect by preferentially interacting with the abundant anionic phospholipids in the bacterial membrane. |
| In vitro study | Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei. |
Magainin 2 (Xenopus laevis) - Risk and Safety
| WGK Germany | 3 |
Magainin 2 (Xenopus laevis) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.405 ml | 2.027 ml | 4.054 ml |
| 5 mM | 0.081 ml | 0.405 ml | 0.811 ml |
| 10 mM | 0.041 ml | 0.203 ml | 0.405 ml |
| 5 mM | 0.008 ml | 0.041 ml | 0.081 ml |
Last Update：2024-01-02 23:10:35
Magainin 2 (Xenopus laevis) - Uses and synthesis methods
in vitro studies
Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei.
Last Update：2024-04-10 22:29:15
Magainin 2 (Xenopus laevis) - Reference Information
| biological activity | Magainin 2 (Magainin II) is an antibacterial peptide (AMP), isolated from Xenopus laevis skin. Magainin 2 showed antibiotic activity against many Gram-negative and Gram-positive bacteria. Magainin 2 is also active against protozoa. Magainin 2 exerts a cytotoxic effect by preferentially interacting with the abundant anionic phospholipids in the bacterial membrane. |
| in vitro study | Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, A protozoan, in pond water used an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (large than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, main accumulating in mitochondria and nuclei. |
Last Update：2024-04-09 21:31:58
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Product Name: Magainin II Visit Supplier Webpage Request for quotationCAS: 108433-95-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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